和田真実 (Masami WADA)

准教授

埼玉県出身 大阪大学大学院医学研究科修了　博士（医学）

[専門]　ウイルス学、分子生物学、生化学

[Link1] https://researchmap.jp/masami-wada

mawada (A) med.shimane-u.ac.jp   (A)は、アットマークへ変更

論文

1. Wada M^$, Morita C, Ohsaki E, Ueda K^$. Cell-intrinsic regulation of HBV RNAs by the nonsense-mediated mRNA decay pathway controls viral replication. iScience 28(5):112460(2025) (^$: Corresponding author)
2. Abueldahab L, Suwanmanee Y, Muriungi N, Ohsaki E, Wada M, Kimura-Ohba S, Ueda K. Analysis of the Functional Role of TIMM29 in the Hepatitis B Virus Life Cycle. Microbiol Immunol 69(4): 229-246 (2025)
3. Morita C, Wada M, Ohsaki E, Kimura-Ohba S, Ueda K. Generation of Replication-Competent Hepatitis B Virus Harboring Tagged Polymerase for Visualization and Quantification of the Infection. Microbiol Immunol 69(1): 43-58 (2025)
4. Du K, Ohsaki E, Wada M, Ueda K. Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis. Curr Issues Mol Biol 45(1): 752-765 (2023)
5. Suwanmanee Y, Wada M, Ueda K. Functional roles of GRP78 in hepatitis B virus infectivity and antigen secretion. Microbiol Immunol 65(5): 189-203 (2021)
6. Hossain MG, Mahmud MM, Rahman MA, Akter S, Nazir KHMNH, Saha S, Wada M, Ohsaki E, Honda T, Ueda K. Complete Genome Sequence of a Precore-Defective Hepatitis B Virus Genotype D2 Strain Isolated in Bangladesh. Microbiol Resour Announc 9(11): e00083-20 (2020)
7. Mori H, Fukuhara T, Ono C, Tamura T, Sato A, Fauzyah Y, Wada M, Okamoto T, Noda T, Yoshimori T, Matsuura Y. Induction of selective autophagy in cells replicating hepatitis C virus genome. J Gen Virol 99(12): 1643-1657 (2018)
8. Nakagawa K, Narayanan K, Wada M, Popov VL, Cajimat M, Baric RS, Makino S. The Endonucleolytic RNA Cleavage Function of nspl of Middle East Respiratory Syndrome Coronavirus Promotes the Production of Infectious Virus Particles in Specific Human Cell Lines. J Virol 92(21): e01157-18 (2018)
9. Wada M, Lokugamage KG, Nakagawa K, Narayanan K, Makino S. Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway. Proc Natl Acad Sci U S A115(43): E10157-E10166 (2018)
10. Nakagawa K, Narayanan K, Wada M, Makino S. Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication. J Virol 92(20): e00902-18 (2018)
11. Yamamoto S, Fukuhara T, Ono C, Uemura K, Kawachi Y, Shiokawa M, Mori H, Wada M, Shima R, Okamoto T, Hiraga N, Suzuki R, Chayama K, Wakita T, Matsuura Y. Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus. PLoS Pathog 12(5): e1005610 (2016)
12. Fukuhara T^#, Wada M^#, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y. Amphipathic a-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles. PLoS Pathog 10(12): e1004534 (2014) (^#: equal contribution)
13. Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E. Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice. PLoS One 9(8): e105423 (2014)
14. Wada M, Tamura A, Takahashi N, Tsukita S. Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition. Gastroenterology 144(2): 369-380 (2013)
15. Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, Tsukita S. Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine. Gastroenterology 140(3): 913-923 (2011)
16. Higuchi K, Iizasa H, Sai Y, Horieya S, Lee KE, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang YS, Nakashima E. Differential Expression of Ezrin and CLP36 in the Two Layers of Syncytiotrophoblast in Rats. Biol Pharm Bull33(8): 1400-1406 (2010)
17. Yamazaki Y, Umeda K, Wada M, Nada S, Okada M, Tsukita S, Tsukita S. ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens. Mol Biol Cell 19(9): 3801-3811 (2008)

研究費

文部科学省科学研究補助金

令和４年度–令和７年度　基盤研究C (代表) 22K07087「新規遺伝子操作系による組換えHBVを用いたHBV polymerase動態解析」

令和1年度–令和３年度　若手研究 (代表) 19K16668「ナンセンスコドン介在的mRNA分解を介したHBV mRNAs分解機構の解析」

国立研究開発法人日本医療研究開発機構（AMED)

令和６年度–令和７年度　肝炎等克服実用化研究事業 Ｂ型肝炎創薬実用化等研究事業

「B型肝炎ウイルス（HBV）感染・増殖に関わるウイルス-宿主相互作用連関の解明による抗HBV戦略の展開」