• Department of Microbiology, Faculty of Medicine, Shimane Univsresity

飯笹久 (Hisashi IIZASA)

教授

神奈川県出身 金沢大学大学院単位取得退学　博士（薬学）

[専門]　ウイルス学、細菌学、分子生物学、腫瘍学

[Link1] https://researchmap.jp/read0056338

[Link2] https://scholar.google.com/citations?user=7PlQPWYAAAAJ

[趣味]　読書、音楽全般

iizasah (A) med.shimane-u.ac.jp   (A)は、アットマークへ変更

 

主要論文

  1. Liu Y, Tumurgan Z, Wai AP, Akter M, Wadi AFAA, Mizukami Y, Wada M, Okada S, Niino D, Murata T, Iizasa H*, Yoshiyama H*. SFK inhibition suppresses EBV-encoded BART miRNAs and induces apoptosis in EBV-positive gastric epithelial cells. Cancers 18(7):1082(2026) (*Corresponding author)
  2. Muchtar A#, Onomura D#, Ding D, Nishitsuji H, Shimotono K, Okada S, Ueda K, Watashi K, Wakita T, Iida K, Yoshiyama H*, Iizasa H*. MicroRNA-3145 as a Potential Therapeutic Target for Hepatitis B Virus: Inhibition of Viral Replication via Downregulation of HBS and HBX. Front Microbiol15:1499216 (2025)  (*Corresponding author, #Equal contribution)
  3. Liu Y, PhyoWai A, Iida Y, Tumurgan Z, Okada S, Iizasa H*, Yoshiyama H*. Exploring the anti-EBV potential of suberoylanilide hydroxamic acid: leading apoptosis in infected cells by suppressing BART gene expression and inducing lytic infection. Virology 597:110161 (2024)  (*Corresponding author) .
  4. Wadi AFAA, Onomura D, Funamori H, Khatun MM, Okada S, Iizasa H, Yoshiyama H. Effect of strain differences, humidity changes, and saliva contamination on inactivation of SARS-CoV-2 by ions. Viruses 16(4):520 (2024)
  5. Heawchaiyaphum C, Pientong C, Yoshiyama H, Iizasa H, Panthong W, Ekalaksananan General features and novel gene signatures that identify Epstein-Barr virus-associated epithelial cancers. Cancers 14(1): 31 (2022).
  6. Fekadu S#, Kanehiro Y#, Kartika AV, Hamada K, Sakurai N, Mizote T, Akada J, Yamaoka Y, Iizasa H*, Yoshiyama H*. Helicobacter pylori Promotes Epstein-Barr Virus Infection by Inducing EphA2 and NMHC-IIA Receptors on Gastric Epithelial Cells. Cancer Sci 112(11): 4799-4811 (2021).(#Equal contribution, *Corresponding author
  7. Liang S, Takahashi H, Hirose T, Kuramitsu Y, Hatakeyama S, Wang R, Yoshiyama H, Hamada J*, Iizasa H*. NONO is a negative regulator of SOX2 promoter. Cancer Genom Proteom 17(4):359-367 (2020). (*Corresponding author
  8. Iizasa H, Kim H, Kartika AV, Kanehiro Y, Yoshiyama H*. Role of viral and host microRNAs in immune regulation of Epstein-Barr virus-associated diseases.  Front Immunol  (*Corresponding author)
  9. Liu G, Ma X, Wang Z, Wakae K, Yuan Y, He Z, Yoshiyama H, Iizasa H, Zhang H, Matsuda M, Sugiyama R, Yuan Z, Muramatsu M, Li L. Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HBV replication by enhancing microRNA-122 processing. J Biol Chem 294(38):14043-14054 (2019)
  10. Nishikawa J, Iizasa H, Yoshiyama H, Kanami S, Kobayashi Y, Sasaki S, Nakamura M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I. Clinical Importance of Epstein-Barr Virus-associated Gastric Cancer. Cancers10 (6): 167 (2018)
  11. Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H. Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor.  J Virol 89(5): 2684-2697 (2015) 
  12. Ota H, Sakurai M, Gupta, R, Valente L, Wulff B-E, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing. Cell 153 (3) : 578-589 (2013)
  13. Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi, M, Irimura T, Hamada J. Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. Cancer Lett 339 (1) : 82-92 (2013)
  14. Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J, Iizasa H*. Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochem Biophys Res Commun 437 (2) : 205-211 (2013). (*Corresponding author)
  15. Iizasa H*, Nanbo A*, Nishikawa J, Jinushi M, Yoshiyama H. EBV-associated gastric carcinoma. Viruses 4 (12) : 3420-3439 (2012) (*Equal contribution)
  16. Iizasa H, Wulff B-E, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A,Showe L,Lieberman P,Nishikura K. Editing of EBV-encoded BART6 microRNAs controls their Dicer targeting and consequently affects viral latency. J Biol Chem285 (43) : 33358-33370 (2010)
  17. Iizasa H, Nishikura K. A new function for the RNA-editing enzyme ADAR1. Nat Immunol 10 (1) : 16-18, (2009)
  18. Kawahara Y, Megraw M, Kreider E, Iizasa H, Valente L, Hatzigeorgiou AG, Nishikura K. Frequency and fate of microRNA editing in human brain. Nucleic Acids Res 36 (16) : 5270-5280 (2008)
  19. Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315 (5815) : 1137-1140 (2007)
  20. Iizasa H, Yoneyama H, Mukaida N, Katakoka Y, Naito M, Yoshida N, Nakashima E, Matsushima K. Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production. J Immunol 174 (6) : 3273-3280 (2005)
  21. Asashima T, Iizasa H, Terasaki T, Nakashima E. Rat brain pericyte cell lines expressing beta2-adrenergic receptor, angiotensin II receptor type 1A, klotho, and CXCR4 mRNAs despite having endothelial cell markers. J Cell Physiol 197 (1) : 69-76 (2003)
  22. Iizasa H, Genda N, Kitano T, Tomita M, Nishihara K, Hayashi M, Nakamura K, Kobayashi S, Nakashima E. Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice. J Pharm Sci 92 (11) : 569-576 (2003)
  23. Asashima T, Iizasa H, Terasaki T, Hosoya K, Tetsuka K, Ueda M, Obinata M, Nakashima E. Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-β1 and β-glycerophosphate. Eur J Cell Biol 81 (3) : 145-152 (2002)
  24. Kawabata K, Ujikawa M, Egawa T, Kawamoto H, Tachibana K, Iizasa H, Katsura Y, Kishimoto T, Nagasawa T. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci U S A 96(10): 5663-5667 (1999)
  25. Tachibana K, Hirota S*, Iizasa H*, Yoshida H*, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393 (6685): 591-594 (1998). (*Equal contribution)
  26. Tachibana K, Nakajima T, Sato A, Igarashi K, Shida H, Iizasa H, Yoshida N, Yoshie O, Kishimoto T, Nagasawa T. CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry. J Exp Med 185(10): 1865-1870 (1997)
  27. Kuno K, Iizasa H, Ohno S, Matsushima K. The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TSP motifs. Genomics46(3): 466-471 (1997)
  28. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, Kishimoto T. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A 93(25): 14726-14729 (1996)

主要著書　

  1. 飯笹久. 第４節mRNA医薬品の技術動向（第6章 mRNA医薬の基盤技術開発、核酸医薬・mRNA医薬の製造分析の基礎と基盤技術開発）. 小比賀 聡、井上 貴雄　監. CMCリサーチ, 東京 p249-262 (2023).
  2. Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H*. “MicroRNAs and oncogenic human viruses.” MicroRNAs: Key Regulators of Oncogenesis. (Ed. Sadegh Babashah) Springer, p155-182 (2014).(*Corresponding author)
  3. Valente L, Kawahara Y, Zinshteyn B, Iizasa H, Nishikura K. Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing. Post-transcriptional gene regulation: RNA processing in eukaryotes. (Ed. Jane Y.Wu) Wiley-VCH Verlag GmbH, p41-82 (2013).
  4. Iizasa H, Matsushima K. IL-8. Academic Press Cytokine Reference. (Ed. Oppenheim JJ, Feldmann M, Durum SK, Hirano T, Vilcek J, Nicola NA) Academic Press. p1061-1067 (2000).

主要特許

  1. 吉山裕規, 飯笹久, キムヒョジ（出願人 国立大学法人 島根大学）. Epstein-Barrウイルス関連癌に特異的な抗腫瘍剤. 特願2017-160164 (2017)
  2. IIZASA Hisashi, HATTORI Kenji, NAKASHIMA Emi, TERASAKI Tetsuya, OBINATA Masuo. Immortalized vascular adventital cell line. EU Patent, EP 1 256 625 B1, 2010

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